A single gene connects stiffness in glaucoma and the vascular system
T Borrás - Experimental eye research, 2017 - Elsevier
Arterial calcification results in arterial stiffness and higher systolic blood pressure. Arterial
calcification is prevented by the high expression of the Matrix-Gla gene (MGP) in the
vascular smooth muscle cells (VSMC) of the arteries' tunica media. Originally, MGP, a gene
highly expressed in cartilage and VSMC, was found to be one of the top expressed genes in
the trabecular meshwork. The creation of an Mgp-lacZ Knock-In mouse and the use of
mouse genetics revealed that in the eye, Mgp's abundant expression is localized and …
calcification is prevented by the high expression of the Matrix-Gla gene (MGP) in the
vascular smooth muscle cells (VSMC) of the arteries' tunica media. Originally, MGP, a gene
highly expressed in cartilage and VSMC, was found to be one of the top expressed genes in
the trabecular meshwork. The creation of an Mgp-lacZ Knock-In mouse and the use of
mouse genetics revealed that in the eye, Mgp's abundant expression is localized and …