Here we use single-cell RNA sequencing to compile a human breast cell atlas assembled
from 55 donors that had undergone reduction mammoplasties or risk reduction
mastectomies. From more than 800,000 cells we identified 41 cell subclusters across the
epithelial, immune and stromal compartments. The contribution of these different clusters
varied according to the natural history of the tissue. Age, parity and germline mutations,
known to modulate the risk of developing breast cancer, affected the homeostatic cellular …

In this study we use single cell RNA sequencing to compile a human breast cell atlas
assembled from 55 donors that had undergone reduction mammoplasties or risk reduction
mastectomies. From more than 800,000 cells we identified 41 cell subclusters across the
epithelial, immune, and stromal compartments. The contribution of these different clusters
varied according to the natural history of the tissue. Age, parity, and germline mutations,
known to modulate the risk of developing breast cancer, affected the homeostatic cellular …