A single-dose live-attenuated vaccine prevents Zika virus pregnancy transmission and testis damage

C Shan, AE Muruato, BW Jagger, J Richner… - Nature …, 2017 - nature.com
… of sexual transmission. Here we demonstrate that live-attenuated Zika virus vaccine candidates
… in the 3′ untranslated region of the Zika virus genome (ZIKV-3′UTR-LAV) prevent viral

A single-dose plasmid-launched live-attenuated Zika vaccine induces protective immunity

J Zou, X Xie, H Luo, C Shan, AE Muruato… - …, 2018 - thelancet.com
… To achieve this goal, we have developed a single-dose DNA-launched LAV that … single-dose
live-attenuated vaccine prevents Zika virus pregnancy transmission and testis damage

A single-dose live-attenuated vaccine prevents Zika virus pregnancy transmission and testis damage

BW Jagger, J Richner, MS Diamond - 2017 - digitalcommons.wustl.edu
… of sexual transmission. Here we demonstrate that live-attenuated Zika virus vaccine candidates
… in the 3′ untranslated region of the Zika virus genome (ZIKV-3′UTR-LAV) prevent viral

A single-dose live-attenuated Zika virus vaccine with controlled infection rounds that protects against vertical transmission

X Xie, DB Kum, H Xia, H Luo, C Shan, J Zou… - Cell host & …, 2018 - cell.com
… use in pregnant women is critically needed. Toward this goal, we have developed a single-dose
live-attenuated vaccine … The vaccine contains a 9-amino-acid deletion in the viral capsid …

A systematic approach to the development of a safe live attenuated Zika vaccine

SS Kwek, S Watanabe, KR Chan, EZ Ong… - Nature …, 2018 - nature.com
Zika virus (ZIKV) is a flavivirus that can cause congenital … (LAV) would be advantageous,
as a single dose of YF17D … (brain) or sexual transmission of the virus (testes and kidney) 17 . …

Live vaccine infection burden elicits adaptive humoral and cellular immunity required to prevent Zika virus infection

C Yau, ES Gan, SS Kwek, HC Tan, EZ Ong… - …, 2020 - thelancet.com
… yellow fever live attenuated vaccine (YF17D) … prevent infection of certain organs such as
the testes, highlighting their possible necessity in preventing silent transmission from vaccinated

Zika virus—an update on the current efforts for vaccine development

VAS Lunardelli, JDS Apostolico… - Human Vaccines & …, 2021 - Taylor & Francis
… in mice and rhesus macaques, also preventing pregnancy transmission and testis damage
in mice. Citation29 Similarly, a single-dose of plasmid-launched live-attenuated ZIKV …

Rational development of live-attenuated Zika virus vaccines

A Adam, C Lee, T Wang - Pathogens, 2023 - mdpi.com
… ZIKV challenges and prevent maternal transmission to the fetus [63]… A single dose of this
attenuated virus was able to trigger … from viral transmission during pregnancy and testis damage

Development of a chimeric Zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone

XF Li, HL Dong, HJ Wang, XY Huang, YF Qiu… - Nature …, 2018 - nature.com
Zika virus (ZIKV) is a mosquito-borne virus belonging to the … Viral RNA was barely
detectable in the spleens and testis of … In our study, a single dose of ChinZIKV can induce high …

Protective efficacy of nucleic acid vaccines against transmission of zika virus during pregnancy in mice

BW Jagger, KA Dowd, RE Chen, P Desai… - The Journal of …, 2019 - academic.oup.com
… who received the live-attenuated tetravalent Dengvaxia vaccine and were subsequently …
One caveat to our studies in mice and their potential to prevent vertical transmission of ZIKV …