Objective To identify the most robust molecular biomarkers in sperm and seminal plasma for
the diagnosis of male infertility, and to evaluate their clinical use. Design Systematic review.
Setting Not applicable. Patient (s) Accessible studies reporting well-defined (in) fertile
populations and semen molecular biomarkers were included in this review. Intervention (s)
A systematic search of the literature published in MEDLINE-PubMed and EMBASE
databases was performed, following Preferred Reporting Items for Systematic Reviews and …

I read with interest the original article titled ''A systematic review identifying fertility
biomarkers in semen: a clinical approach through Omics to diagnose male
infertility''published in the August issue of your esteemed journal. Male infertility factors pose
dire challenges to the treating physician. Although, with the advent of intracytoplasmic sperm
injection, the male infertility factors can be overcome to a great extent, failures with
intracytoplasmic sperm injection point to unknown underlying mechanisms and a better …