A theoretical three-dimensional model for lactoperoxidase and eosinophil peroxidase built on the scaffold of the myeloperoxidase X-ray structure
Lactoperoxidase (LPO), eosinophil peroxidase (EPO) and myeloperoxidase (MPO) belong
to the class of haloperoxidase, a group of mammalian enzymes able to catalyze the
peroxidative oxidation of halide and pseudohalide, like thiocyanate. They all play a key role
in the development of antibacterial activity, whereas the homology in functional role is
emphasized by the striking similarity of their primary structures. A theoretical model for the
tridimensional structure of LPO and EPO has been elaborated on the basis of MPO X-ray …
to the class of haloperoxidase, a group of mammalian enzymes able to catalyze the
peroxidative oxidation of halide and pseudohalide, like thiocyanate. They all play a key role
in the development of antibacterial activity, whereas the homology in functional role is
emphasized by the striking similarity of their primary structures. A theoretical model for the
tridimensional structure of LPO and EPO has been elaborated on the basis of MPO X-ray …
A theoretical three-dimensional model for lactoperoxidase and eosinophil peroxidase, built on the scaffold of the myeloperoxidase X-ray structure
D Gioia, EM Ghibaudi, E Laurenti, M Salmona… - JBIC Journal of …, 1996 - Springer
Abstract Lactoperoxidase (LPO), eosinophil peroxidase (EPO) and myeloperoxidase (MPO)
belong to the class of haloperoxidases, a group of mammalian enzymes able to catalyze the
peroxidative oxidation of halides and pseudohalides, such as thiocyanate. They all play a
key role in the development of antibacterial activity. The homology in their functional role is
emphasized by the striking similarity of their primary structures. A theoretical model for the
three-dimensional structure of LPO and EPO has been developed on the basis of the X-ray …
belong to the class of haloperoxidases, a group of mammalian enzymes able to catalyze the
peroxidative oxidation of halides and pseudohalides, such as thiocyanate. They all play a
key role in the development of antibacterial activity. The homology in their functional role is
emphasized by the striking similarity of their primary structures. A theoretical model for the
three-dimensional structure of LPO and EPO has been developed on the basis of the X-ray …
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