A unified framework for dopamine signals across timescales
… Our results demonstrate that ramping dopamine signals are … dopamine signals can be
driven by a dynamic stimulus that indicates a gradual approach to a reward. We provide a unified …
driven by a dynamic stimulus that indicates a gradual approach to a reward. We provide a unified …
Spatial and temporal scales of dopamine transmission
… Together, these observations have led to the model that dopamine signals through
volume … First, dopamine release occurs on a millisecond timescale and has a high release …
volume … First, dopamine release occurs on a millisecond timescale and has a high release …
A Unified Framework for Dopamine Signals Across Timescales
AN Malik, HGR Kim, N Uchida - Neurosurgery, 2020 - search.proquest.com
… dopamine signals in the brain are consistent with RPEs rather than value. We provide a
unified … We provide a unified computational understanding of rapid phasic and slowly ramping …
unified … We provide a unified computational understanding of rapid phasic and slowly ramping …
A unidirectional but not uniform striatal landscape of dopamine signaling for motivational stimuli
W van Elzelingen, J Goedhoop… - Proceedings of the …, 2022 - National Acad Sciences
… In summary, we demonstrate that dopamine signals across the striatum homogeneously
encode stimulus valence and prediction of motivational stimuli (of both positive and negative …
encode stimulus valence and prediction of motivational stimuli (of both positive and negative …
The role of state uncertainty in the dynamics of dopamine
… Reinforcement learning models of the basal ganglia map the phasic dopamine signal to
reward prediction errors (RPEs). Conventional models assert that, when a stimulus predicts a …
reward prediction errors (RPEs). Conventional models assert that, when a stimulus predicts a …
Dopamine encodes real-time reward availability and transitions between reward availability states on different timescales
… Reward or cue linked phasic dopamine signals can be mimicked using optogenetics to
affect learning and modulate conditioned responding 9,10 . However, not all aspects of …
affect learning and modulate conditioned responding 9,10 . However, not all aspects of …
Explaining dopamine through prediction errors and beyond
… dopamine signals update an internal state transition and reward model, which then guides
behavior through … (which could potentially happen at fast timescales, in addition to slower trial-…
behavior through … (which could potentially happen at fast timescales, in addition to slower trial-…
Wave-like dopamine dynamics as a mechanism for spatiotemporal credit assignment
… We first focused on spontaneous DA signals in a dark chamber without external stimuli. To
test whether DA responses are globally synchronized, we compared fluorescence signals in …
test whether DA responses are globally synchronized, we compared fluorescence signals in …
Mesoaccumbal dopamine heterogeneity: what do dopamine firing and release have to do with it?
… -based and model-free signals throughout the striatum to better … A unified framework for
dopamine signals across timescales … e25 This study argues that dopamine activity and release is …
dopamine signals across timescales … e25 This study argues that dopamine activity and release is …
Mesolimbic dopamine adapts the rate of learning from action
LT Coddington, SE Lindo, JT Dudman - Nature, 2023 - nature.com
… mesolimbic dopamine produced … dopamine signals to set an adaptive rate, not an error
signal, for behavioural policy learning. This work provides strong evidence that phasic dopamine …
signal, for behavioural policy learning. This work provides strong evidence that phasic dopamine …