A validated gene expression model of high-risk multiple myeloma is defined by deregulated expression of genes mapping to chromosome 1
JD Shaughnessy Jr, F Zhan, BE Burington, Y Huang… - Blood, 2007 - ashpublications.org
To molecularly define high-risk disease, we performed microarray analysis on tumor cells
from 532 newly diagnosed patients with multiple myeloma (MM) treated on 2 separate
protocols. Using log-rank tests of expression quartiles, 70 genes, 30% mapping to
chromosome 1 (P<. 001), were linked to early disease-related death. Importantly, most up-
regulated genes mapped to chromosome 1q, and down-regulated genes mapped to
chromosome 1p. The ratio of mean expression levels of up-regulated to down-regulated …
from 532 newly diagnosed patients with multiple myeloma (MM) treated on 2 separate
protocols. Using log-rank tests of expression quartiles, 70 genes, 30% mapping to
chromosome 1 (P<. 001), were linked to early disease-related death. Importantly, most up-
regulated genes mapped to chromosome 1q, and down-regulated genes mapped to
chromosome 1p. The ratio of mean expression levels of up-regulated to down-regulated …
A Validated Gene Expression Signature of High Risk Multiple Myeloma Is Defined by Deregulated Expression of Genes Mapping to Chromosome 1.
JD Shaughnessy Jr, F Zhan, B Burington, Y Huang… - 2006 - ashpublications.org
In an effort to better define the molecular mechanisms of aggressiveness in multiple
myeloma (MM), we performed microarray analysis on tumor cells from 532 newly diagnosed
patients treated on two separate protocols. We hypothesized that expression extremes of a
subset of genes linked to poor survival might point to important regions of the genome that
when amplified or deleted may lead to altered expression of resident genes and hence
disease progression. Using log rank tests of expression quartiles, 70 genes, 30% mapping …
myeloma (MM), we performed microarray analysis on tumor cells from 532 newly diagnosed
patients treated on two separate protocols. We hypothesized that expression extremes of a
subset of genes linked to poor survival might point to important regions of the genome that
when amplified or deleted may lead to altered expression of resident genes and hence
disease progression. Using log rank tests of expression quartiles, 70 genes, 30% mapping …
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