ATP and T-cell-mediated rejection

E Castillo-Leon, S Dellepiane… - Current Opinion in Organ …, 2018 - journals.lww.com
… In particular, extracellular ATP (eATP) significantly influences T-lymphocyte activation
and phenotype. The purpose of this review is to discuss the role of ATP signaling in the T-cell-mediated …

Oxidized-ATP Attenuates Kidney Allograft Rejection By Inhibiting T-Cell, B-Cell, and Macrophage Activity

X Ding, NA Wilson, RR Redfield III, SE Panzer… - Kidney360, 2020 - journals.lww.com
… oATP attenuated T cellmediated rejection and antibody-mediated rejection. (A) All six …
severe mixed rejection (T cellmediated rejection [TCMR] and antibody-mediated rejection […

[HTML][HTML] USP25 deficiency promotes T cell dysfunction and transplant acceptance via mitochondrial dynamics

J Li, J Wang, T Pan, X Zhou, H Yang, L Wang… - International …, 2023 - Elsevier
T cell-mediated solid-organ allograft rejection. Subsequently, to explore the role of USPs in
T cell mediated allo-rejection… the changes of mitochondria with ATP supplement in vivo. Flow …

[HTML][HTML] Oxidized ATP Suppresses B Lymphocyte Activity to Attenuate Antibody-mediated Rejection of Kidney Allografts in Mice

Y Yu, Z Bi, Q Jiang, S Huang, Y He, J Gai… - …, 2024 - journals.lww.com
… Purified B cells were isolated from the spleen of Balb/C mice and cultured with oxidized ATP
at … ATP were examined in a presensitized animal model where kidney allograft rejection

[HTML][HTML] Increased degradation of ATP is driven by memory regulatory T cells in kidney transplantation tolerance

M Durand, F Dubois, C Dejou, E Durand, R Danger… - Kidney International, 2018 - Elsevier
… (a) In vitro adenosine triphosphate (ATP) degradation percentage by sorted mTregs cultured
for 30 minutes in the presence of 10 μM ATP for tolerant patients with stable kidney graft …

[HTML][HTML] Landscape of innate immune system transcriptome and acute T cellmediated rejection of human kidney allografts

FB Mueller, H Yang, M Lubetzky, A Verma, JR Lee… - JCI insight, 2019 - ncbi.nlm.nih.gov
… genes in biopsies categorized as acute T cellmediated rejection (TCMR) compared with …
extracellular ATP by P2X7R promotes calcium influx and activation of the intracellular ATP

Purinergic control of T cell activation by ATP released through pannexin-1 hemichannels

U Schenk, A Westendorf, E Radaelli, A Casati… - Swiss Medical …, 2009 - air.unimi.it
… Conclusions: These preliminary data indicate that CD69 measurement may be a useful
tool and is actually more sensitive to detect T-cell mediated responses than the LTT. …

Self-Regulation of memory CD8 T cell metabolism through extracellular ATP signaling

KM Wanhainen, SC Jameson, HB da Silva - Immunometabolism, 2019 - journals.lww.com
ATP (eATP) … ATP levels, which at first glance would seem to be detrimental for sustained
T cell maintenance. On the other hand, the need to tightly regulate levels of intracellular ATP

Foxp3+ CD4+ T cell-mediated immunosuppression involves extracellular nucleotide catabolism

MS Bynoe, C Viret - Trends in immunology, 2008 - cell.com
… involved in the T cell-mediated suppression of … T cell-mediated immunoregulation in more
than one way. Besides controlling adenosine generation, CD39 catalytic activity removes ATP

[HTML][HTML] Blockade of extracellular ATP effect by oxidized ATP effectively mitigated induced mouse experimental autoimmune uveitis (EAU)

R Zhao, D Liang, D Sun - PLoS One, 2016 - journals.plos.org
… Activation of P2 receptors by ATP effectively modulates various immune … , ATP release
resulted in a lowered threshold for activation and T cellmediated immunopathology [3,5,16]; ATP