Aberrant Notch3 and Notch4 expression in human hepatocellular carcinoma
L Gramantieri, C Giovannini, A Lanzi… - Liver …, 2007 - Wiley Online Library
Background: Notch signalling is altered in several solid tumours and it plays a role in growth
inhibition and apoptosis of hepatocellular carcinoma (HCC)‐derived cell lines, bile duct
development and hepatocyte regeneration. Aims: This study aims to analyse the expression
of Notch3, Notch4 and HES1 and HES6 as Notch‐target genes in HCC, matched non‐
neoplastic tissue and HEPG2 cells. Results: Notch3 and Notch4 are not expressed in normal
liver and in chronic hepatitis surrounding HCC. Cirrhotic tissue stains negative for Notch3 …
inhibition and apoptosis of hepatocellular carcinoma (HCC)‐derived cell lines, bile duct
development and hepatocyte regeneration. Aims: This study aims to analyse the expression
of Notch3, Notch4 and HES1 and HES6 as Notch‐target genes in HCC, matched non‐
neoplastic tissue and HEPG2 cells. Results: Notch3 and Notch4 are not expressed in normal
liver and in chronic hepatitis surrounding HCC. Cirrhotic tissue stains negative for Notch3 …
[PDF][PDF] Aberrant Notch3 and Notch4 expression in human hepatocellular carcinoma
Background: Notch signalling is altered in several solid tumours and it plays a role in growth
inhibition and apoptosis of hepatocellular carcinoma (HCC)-derived cell lines, bile duct
development and hepatocyte regeneration. Aims: This study aims to analyse the expression
of Notch3, Notch4 and HES1 and HES6 as Notch-target genes in HCC, matched non-
neoplastic tissue and HEPG2 cells. Results: Notch3 and Notch4 are not expressed in normal
liver and in chronic hepatitis surrounding HCC. Cirrhotic tissue stains negative for Notch3 …
inhibition and apoptosis of hepatocellular carcinoma (HCC)-derived cell lines, bile duct
development and hepatocyte regeneration. Aims: This study aims to analyse the expression
of Notch3, Notch4 and HES1 and HES6 as Notch-target genes in HCC, matched non-
neoplastic tissue and HEPG2 cells. Results: Notch3 and Notch4 are not expressed in normal
liver and in chronic hepatitis surrounding HCC. Cirrhotic tissue stains negative for Notch3 …
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