[HTML][HTML] Accumulation of defective interfering viral particles in only a few passages in Vero cells attenuates mumps virus neurovirulence
Immunization programs have implemented live attenuated mumps vaccines which reduced
mumps incidence≥ 97%. Some of the vaccine strains were abandoned due to unwanted
side effects and the genetic marker of attenuation has not been identified so far. Our
hypothesis was that non-infectious viral particles, in particular defective interfering particles
(DIPs), contribute to neuroattenuation. We showed that non-infectious particles of the
mumps vaccine L-Zagreb attenuated neurovirulence of wild type mumps virus 9218/Zg98 …
mumps incidence≥ 97%. Some of the vaccine strains were abandoned due to unwanted
side effects and the genetic marker of attenuation has not been identified so far. Our
hypothesis was that non-infectious viral particles, in particular defective interfering particles
(DIPs), contribute to neuroattenuation. We showed that non-infectious particles of the
mumps vaccine L-Zagreb attenuated neurovirulence of wild type mumps virus 9218/Zg98 …
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