Acetic Acid Promoted Direct Iodination of Terminal Alkynes with N-Iodosuccinimide: Efficient Preparation of 1-Iodoalkynes
M Yao, J Zhang, S Yang, E Liu, H Xiong - Synlett, 2020 - thieme-connect.com
M Yao, J Zhang, S Yang, E Liu, H Xiong
Synlett, 2020•thieme-connect.comAn efficient and highly chemoselective approach for the direct iodination of terminal alkynes
using acetic acid as N-iodosuccinimide activated reagent under metal-free conditions has
been developed. This facile process tolerates a variety of terminal alkynes and provides the
desired products in good to excellent yields (up to 99%).
using acetic acid as N-iodosuccinimide activated reagent under metal-free conditions has
been developed. This facile process tolerates a variety of terminal alkynes and provides the
desired products in good to excellent yields (up to 99%).
An efficient and highly chemoselective approach for the direct iodination of terminal alkynes using acetic acid as N-iodosuccinimide activated reagent under metal-free conditions has been developed. This facile process tolerates a variety of terminal alkynes and provides the desired products in good to excellent yields (up to 99%).
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