Activation of adenosine A2A receptor signaling regulates the expression of cytokines associated with immunologic dysfunction in BTBR T+ Itpr3tf/J mice
Autism spectrum disorder (ASD) is neurodevelopmental disorders characterized by
stereotypical repetitive behavior, impaired social interaction, and deficits in communication.
The BTBR T+ Itpr3 tf/J (BTBR) mice have been extensively used as an animal model of the
ASD-like phenotype. Adenosine A2A receptors (A2ARs) are considered potential targets in
the treatment of neurodegenerative diseases. In this study, we used the A2AR antagonist
SCH 5826 (SCH) and the A2AR agonist CGS 21680 (CGS) to investigate the activation of …
stereotypical repetitive behavior, impaired social interaction, and deficits in communication.
The BTBR T+ Itpr3 tf/J (BTBR) mice have been extensively used as an animal model of the
ASD-like phenotype. Adenosine A2A receptors (A2ARs) are considered potential targets in
the treatment of neurodegenerative diseases. In this study, we used the A2AR antagonist
SCH 5826 (SCH) and the A2AR agonist CGS 21680 (CGS) to investigate the activation of …
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