[HTML][HTML] Activation of liver X receptor induces macrophage interleukin-5 expression
IL-5 stimulates production of T15/EO6 IgM antibodies that can block the uptake of oxidized
low density lipoprotein by macrophages, whereas a deficiency in macrophage IL-5
expression accelerates development of atherosclerosis. Liver X receptors (LXRs) are ligand-
activated transcription factors that can induce macrophage ABCA1 expression and
cholesterol efflux, thereby inhibiting the development of atherosclerosis. However, it remains
unknown whether additional mechanisms, such as the regulation of macrophage IL-5 …
low density lipoprotein by macrophages, whereas a deficiency in macrophage IL-5
expression accelerates development of atherosclerosis. Liver X receptors (LXRs) are ligand-
activated transcription factors that can induce macrophage ABCA1 expression and
cholesterol efflux, thereby inhibiting the development of atherosclerosis. However, it remains
unknown whether additional mechanisms, such as the regulation of macrophage IL-5 …
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