Pharma 4.0 conceptualizes extremely systematic automated processes, which could be batch, continuous, or a hybrid of these, operated by an integrated manufacturing control strategy. Quality by design and process analytical technology principles are used to strengthen the hypothesis of Pharma 4.0. These provide the potential for robust, efficient, and quickproduction. Industry 4.0 is employed in medical technology, health-care facilities, and biopharmaceutical manufacturing. Digital transformation plays a major role. Pharma 4.0 provides better instruments to enforce product safety and supply chain security. This review explains the impact of data analytics technology, digitization, industry 4.0, artificial intelligence, digital twins, and continuous manufacturing and their impact on Pharma 4.0.