Neuroinflammation caused by microglial activation plays a key role in ischemia,
neurodegeneration and many other CNS diseases. In this study, we found that Adjudin, a
potential non-hormonal male contraceptive, exhibits additional function to reduce the
production of proinflammatory mediators. Adjudin significantly inhibited LPS-induced IL-6
release and IL-6, IL-1β, TNF-α expression in BV2 microglial cells. Furthermore, Adjudin
exhibited anti-inflammatory properties by suppression of NF-κB p65 nuclear translocation …