Adult Fmr1 knockout mice present with deficiencies in hippocampal interleukin-6 and tumor necrosis factor-α expression
Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by a single genetic
mutation in the FMR1 gene. Mutations in the FMR1 gene are the largest monogenic cause of
autism spectrum disorder (ASD), and thus both disorders share many of the same cognitive
and behavioral impairments. There is increasing evidence suggesting that dysregulated
immune responses play a role in the pathophysiology of ASD; however, the association
between FXS and altered immunity requires further investigation. This study examined …
mutation in the FMR1 gene. Mutations in the FMR1 gene are the largest monogenic cause of
autism spectrum disorder (ASD), and thus both disorders share many of the same cognitive
and behavioral impairments. There is increasing evidence suggesting that dysregulated
immune responses play a role in the pathophysiology of ASD; however, the association
between FXS and altered immunity requires further investigation. This study examined …
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