Advances in NK cell production

F Fang, S Xie, M Chen, Y Li, J Yue, J Ma… - Cellular & Molecular …, 2022 - nature.com
… the functions of NK cells. Here, we summarize the recent advances in expansion strategies
with or without genetic manipulation of NK cells derived from various cellular sources. We …

The NK cell–cancer cycle: advances and new challenges in NK cell–based immunotherapies

T Bald, MF Krummel, MJ Smyth, KC Barry - Nature immunology, 2020 - nature.com
NK cell function. In this Review, we introduce the NK cell–cancer cycle to highlight recent
advances in NK cell biology and to discuss the progress and problems of NK cell–based …

Arming immune cells for battle: A brief journey through the advancements of T and NK cell immunotherapy

P Wendel, LM Reindl, T Bexte, L Künnemeyer… - Cancers, 2021 - mdpi.com
… on the history and recent advances of T cell and natural killer (NK) cell-based … of T cells
in the 1960s, and NK cells were first described in 1975, the clinical application of adoptive cell

Advances in clinical NK cell studies: donor selection, manufacturing and quality control

U Koehl, C Kalberer, J Spanholtz, DA Lee… - …, 2016 - Taylor & Francis
… A phase I study of in vitro expanded natural killer T cells in patients with advanced and
recurrent non-small cell lung cancer. Clin Cancer Res 2006; 12:6079-86; PMID:17028247; http://…

Advances in NK cell therapy for hematologic malignancies: NK source, persistence and tumor targeting.

A Merino, J Maakaron, V Bachanova - Blood reviews, 2023 - Elsevier
… Further highlighting the importance of NK cell dose, a phase I study of HLA-haploidentical
NK cells … a significant association between CD56 + NK cells infused and overall survival [66]. …

Advances in NK cell therapy for brain tumors

J Fares, ZB Davis, JS Rechberger, SA Toll… - NPJ Precision …, 2023 - nature.com
… being used to create NK cell products that subvert … NK cell-based immunotherapies that
target several neuro-malignancies and highlight advances in molecular imaging of NK cells that …

The advances and challenges of NK cell-based cancer immunotherapy

S Kang, X Gao, L Zhang, E Yang, Y Li, L Yu - Current Oncology, 2021 - mdpi.com
… receptor along with CD3 subunits (TCR-NK) has been developed to increase the reactivity
… of NK cells toward tumor cells. Here, we review recent advances in redirecting NK cells for …

Challenges and recent advances in NK cell-targeted immunotherapies in solid tumors

G Lian, TSK Mak, X Yu, HY Lan - International Journal of Molecular …, 2021 - mdpi.com
… In this review, we introduce the challenges that NK cellsadvances and the latest clinical
outcomes of NK-based immunotherapies, as well as promising strategies to optimize current NK-…

[HTML][HTML] Natural killer cell-based immunotherapy for cancer: advances and prospects

Y Hu, Z Tian, C Zhang - Engineering, 2019 - Elsevier
… of tumor escape from NK cell recognition, the current status and advanced progress of NK
cell-based immunotherapy, ways of enhancing the antitumor capacity of NK cells in vivo, and …

[HTML][HTML] NK cell-based immunotherapies in cancer

MH Shin, J Kim, SA Lim, J Kim, SJ Kim, KM Lee - Immune network, 2020 - ncbi.nlm.nih.gov
… Here, we summarize the recent advances in NK cell-based cancer immunotherapies that
have focused on providing improved function through the use of the latest genetic engineering …