[HTML][HTML] Advances in RNA cancer therapeutics: New insight into exosomes as miRNA delivery
L Volpini, F Monaco, L Santarelli, J Neuzil… - Aspects of Molecular …, 2023 - Elsevier
We are now entering a new era of RNA therapies, such that mRNA-based vaccines and
RNA interference approaches such as siRNA have already been launched on the
pharmaceutical market. However, there are no FDA-approved RNA-based therapeutics for
cancer treatment. Among RNA molecules, miRNAs represent a promising solution against
cancer. Despite the ability to target multiple pathways, miRNA-based therapeutics struggle
to reach phase 3 clinical trial. A reason of this delay is linked to complications of selective …
RNA interference approaches such as siRNA have already been launched on the
pharmaceutical market. However, there are no FDA-approved RNA-based therapeutics for
cancer treatment. Among RNA molecules, miRNAs represent a promising solution against
cancer. Despite the ability to target multiple pathways, miRNA-based therapeutics struggle
to reach phase 3 clinical trial. A reason of this delay is linked to complications of selective …
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