Advances in screening for membrane permeability: high-resolution PAMPA for medicinal chemists
M Kansy, A Avdeef, H Fischer - Drug Discovery Today: Technologies, 2004 - Elsevier
The majority of orally administered drugs are described to be passively transported across
the lipophilic cell membranes [Lennernäs, H. et al.(1994) Intestinal drug absorption during
induced net water absorption in human; a mechanistic study using antipyrine, atenolol and
enalaprilat. Br. J. Clin. Pharmacol. 37, 589–596; Artursson, P. Application of
physicochemical properties of molecules to predict intestinal permeability. Proceedings of
the AAPS Workshop on Permeability Definitions and Regulatory Standards, Arlington, VA …
the lipophilic cell membranes [Lennernäs, H. et al.(1994) Intestinal drug absorption during
induced net water absorption in human; a mechanistic study using antipyrine, atenolol and
enalaprilat. Br. J. Clin. Pharmacol. 37, 589–596; Artursson, P. Application of
physicochemical properties of molecules to predict intestinal permeability. Proceedings of
the AAPS Workshop on Permeability Definitions and Regulatory Standards, Arlington, VA …
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