OBJECTIVE: Prophylactic strategies against invasive pulmonary aspergillosis are often
limited by drug interactions and toxicities. Targeted airway delivery of antifungals to the
lungs may avoid these pitfalls. We evaluated the effectiveness of an aerosolized
nanostructured formulation of itraconazole produced by spray freezing into liquid (SFL) as
prophylaxis against invasive pulmonary aspergillosis caused by A. fumigatus. METHODS:
Immunocompromised Balb/C mice received either itraconazole by oral gavage (Sporanox …