[HTML][HTML] Aggregation of polyglutamine-expanded ataxin 7 protein specifically sequesters ubiquitin-specific protease 22 and deteriorates its deubiquitinating function in …
H Yang, S Liu, WT He, J Zhao, LL Jiang… - Journal of Biological …, 2015 - ASBMB
Human ataxin 7 (Atx7) is a component of the deubiquitination module (DUBm) in the Spt-
Ada-Gcn5-acetyltransferase (SAGA) complex for transcriptional regulation, and expansion of
its polyglutamine (polyQ) tract leads to spinocerebellar ataxia type 7. However, how polyQ
expansion of Atx7 affects DUBm function remains elusive. We investigated the effects of
polyQ-expanded Atx7 on ubiquitin-specific protease (USP22), an interacting partner of Atx7
functioning in deubiquitination of histone H2B. The results showed that the inclusions or …
Ada-Gcn5-acetyltransferase (SAGA) complex for transcriptional regulation, and expansion of
its polyglutamine (polyQ) tract leads to spinocerebellar ataxia type 7. However, how polyQ
expansion of Atx7 affects DUBm function remains elusive. We investigated the effects of
polyQ-expanded Atx7 on ubiquitin-specific protease (USP22), an interacting partner of Atx7
functioning in deubiquitination of histone H2B. The results showed that the inclusions or …
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