… acting as the primary culprit in disease is Alexander disease, which is caused by dominant
… how astrocyte function is impaired in Alexander disease, and the strategies we can devise to …

Chapter 57 ularly shaped, elongated or round hyaline eosinophilic bodies up to 50mm in
length with a diameter of 1–25mm. They are arranged radially around blood vessels and …

… Alexander disease. The current data suggest that a combination of events cause the disease.
… These then set in motion events that lead to Alexander disease. We discuss parallels with …

Alexander disease (AD) in its typical form is an infantile lethal leucodystrophy, characterized
pathologically by Rosenthal fibre accumulation. Following the identification of glial fibrillary …

… Our analysis of DNA samples from Alexander disease patients has identified putative
disease-causing mutations in four amino acids in the rod and tail domains of GFAP (Fig. 3). All four …

… Alexander disease is a rare but often fatal disease of the … gene are a cause of Alexander
disease. Sequencing results from … in most cases of the disease, including both the infantile and …

… In this article, we present seven patients with Alexander disease with no or inconspicuous
cerebral white matter abnormalities and no or minimal contrast enhancement. The patients …

Objective: To characterize Alexander disease (AxD) phenotypes and determine correlations
with age at onset (AAO) and genetic mutation. AxD is an astrogliopathy usually …

… of glial fibrillary acidic protein mutations in Alexander disease, we analyzed 41 new patients
and … Alexander disease is a progressive, usually fatal neurological disorder that displays …

… Alexander disease. We searched for GFAP mutations in a series of patients who had
heterogeneous clinical symptoms but were candidates for Alexander disease … Alexander disease, …