Alkaloids from the antarctic sponge Kirkpatrickia varialosa. Part 2: Variolin A and N (3′)-methyl tetrahydrovariolin B
G Trimurtulu, DJ Faulkner, NB Perry, L Ettouati… - Tetrahedron, 1994 - Elsevier
Two pyridopyrrolopyrimidine alkaloids, variolin A (2) and N (3′)-methyl tetrahydrovariolin B
(3), have been isolated from the Antarctic sponge Kirkpatrickia varialosa, and their structures
determined by X-ray crystallography and interpretation of spectral data respectively. N (3′)-
Methyl tetrahydrovariolin B (3) is moderately cytotoxic and showed antifungal activity, while
variolin A (2) is weakly cytotoxic.
(3), have been isolated from the Antarctic sponge Kirkpatrickia varialosa, and their structures
determined by X-ray crystallography and interpretation of spectral data respectively. N (3′)-
Methyl tetrahydrovariolin B (3) is moderately cytotoxic and showed antifungal activity, while
variolin A (2) is weakly cytotoxic.
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