Allelic variations in superoxide dismutase-1 (SOD1) gene and renal and cardiovascular morbidity and mortality in type 2 diabetic subjects
AL Neves, K Mohammedi, N Emery, R Roussel… - Molecular genetics and …, 2012 - Elsevier
BACKGROUND: Oxidative stress is involved in the pathophysiology of renal and
cardiovascular complications of diabetes. Superoxide dismutase (SOD) enzymes play a
major role in detoxification of reactive oxygen species and protection against oxidative
stress. Associations of SOD1 gene variants with diabetic nephropathy were reported in
patients with type 1 diabetes. We investigated associations of allelic variations in SOD1
gene with nephropathy and cardiovascular complications in patients with type 2 diabetes …
cardiovascular complications of diabetes. Superoxide dismutase (SOD) enzymes play a
major role in detoxification of reactive oxygen species and protection against oxidative
stress. Associations of SOD1 gene variants with diabetic nephropathy were reported in
patients with type 1 diabetes. We investigated associations of allelic variations in SOD1
gene with nephropathy and cardiovascular complications in patients with type 2 diabetes …
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