Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau
Background The microtubule-associated protein tau accumulates in neurodegenerative
diseases known as tauopathies, the most common being Alzheimer's disease. One way to
treat these disorders may be to reduce abnormal tau levels through chaperone
manipulation, thus subverting synaptic plasticity defects caused by tau's toxic accretion.
Methods Tauopathy models were used to study the impact of YM-01 on tau. YM-01 is an
allosteric promoter of triage functions of the most abundant variant of the heat shock protein …
diseases known as tauopathies, the most common being Alzheimer's disease. One way to
treat these disorders may be to reduce abnormal tau levels through chaperone
manipulation, thus subverting synaptic plasticity defects caused by tau's toxic accretion.
Methods Tauopathy models were used to study the impact of YM-01 on tau. YM-01 is an
allosteric promoter of triage functions of the most abundant variant of the heat shock protein …
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