[HTML][HTML] Alpha-2, 3-sialyltransferases regulate the multidrug resistance of chronic myeloid leukemia through miR-4701-5p targeting ST3GAL1
Y Li, S Luo, W Dong, X Song, H Zhou, L Zhao… - Laboratory …, 2016 - Elsevier
The aberrant sialylation profile on the surface of leukemia cells has been recognized for its
potential diagnostic value towards assessing leukemia multidrug resistance (MDR).
MicroRNAs as endogenous regulators of gene expression have been implicated in treating
MDR. In this study, we describe the differential expressional profiles of α-2, 3-
sialyltransferases (ST) and miR-4701-5p in three pairs of chronic myeloid leukemia (CML)
cell lines and 48 clinical samples of bone marrow mononuclear cells from CML patients. The …
potential diagnostic value towards assessing leukemia multidrug resistance (MDR).
MicroRNAs as endogenous regulators of gene expression have been implicated in treating
MDR. In this study, we describe the differential expressional profiles of α-2, 3-
sialyltransferases (ST) and miR-4701-5p in three pairs of chronic myeloid leukemia (CML)
cell lines and 48 clinical samples of bone marrow mononuclear cells from CML patients. The …
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