Alpino is a wide-coverage computational analyzer of Dutch which aims at accurate, full, parsing of unrestricted text. We describe the head-driven lexicalized grammar and the lexical component, which has been derived from existing resources. The grammar produces dependency structures, thus providing a reasonably abstract and theory-neutral level of linguistic representation. An important aspect of wide-coverage parsing is robustness and disambiguation. The dependency relations encoded in the dependency structures have been used to develop and evaluate both hand-coded and statistical disambiguation methods.