Alterations in CD39/CD73 axis of T cells associated with COVID‐19 severity
GP Dorneles, PC Teixeira, IM da Silva… - Journal of Cellular …, 2022 - Wiley Online Library
Purinergic signaling modulates immune function and is involved in the
immunopathogenesis of several viral infections. This study aimed to investigate alterations
in purinergic pathways in coronavirus disease 2019 (COVID‐19) patients. Mild and severe
COVID‐19 patients had lower extracellular adenosine triphosphate and adenosine levels,
and higher cytokines than healthy controls. Mild COVID‐19 patients presented lower
frequencies of CD4+ CD25+ CD39+ (activated/memory regulatory T cell [mTreg]) and …
immunopathogenesis of several viral infections. This study aimed to investigate alterations
in purinergic pathways in coronavirus disease 2019 (COVID‐19) patients. Mild and severe
COVID‐19 patients had lower extracellular adenosine triphosphate and adenosine levels,
and higher cytokines than healthy controls. Mild COVID‐19 patients presented lower
frequencies of CD4+ CD25+ CD39+ (activated/memory regulatory T cell [mTreg]) and …
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