Alterations in blood pressure, antioxidant status and caspase 8 expression in cobalt chloride-induced cardio-renal dysfunction are reversed by Ocimum gratissimum …
The protective abilities of the chloroform extract of Ocimum gratissimum (COG) and gallic
acid against cobalt chloride (CoCl 2)− induced cardiac and renal toxicity were evaluated.
Rats were exposed to CoCl 2 (350 ppm) for 7 days, either alone, or in combination with COG
(100 and 200 mg/kg) or gallic acid (120 mg/kg). CoCl 2 given alone, caused significant
increases (p< 0.05) in oxidative stress parameters (hydrogen peroxide, H 2 O 2 and
malondialdehyde, MDA) and increased expression of the apoptotic initiator caspase 8 in the …
acid against cobalt chloride (CoCl 2)− induced cardiac and renal toxicity were evaluated.
Rats were exposed to CoCl 2 (350 ppm) for 7 days, either alone, or in combination with COG
(100 and 200 mg/kg) or gallic acid (120 mg/kg). CoCl 2 given alone, caused significant
increases (p< 0.05) in oxidative stress parameters (hydrogen peroxide, H 2 O 2 and
malondialdehyde, MDA) and increased expression of the apoptotic initiator caspase 8 in the …
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