Amidation of esters with amino alcohols using organobase catalysis
N Caldwell, PS Campbell, C Jamieson… - The Journal of …, 2014 - ACS Publications
A catalytic protocol for the base-mediated amidation of unactivated esters with amino
alcohol derivatives is reported. Investigations into mechanistic aspects of the process
indicate that the reaction involves an initial transesterification, followed by an intramolecular
rearrangement. The reaction is highly general in nature and can be extended to include the
synthesis of oxazolidinone systems through use of dimethyl carbonate.
alcohol derivatives is reported. Investigations into mechanistic aspects of the process
indicate that the reaction involves an initial transesterification, followed by an intramolecular
rearrangement. The reaction is highly general in nature and can be extended to include the
synthesis of oxazolidinone systems through use of dimethyl carbonate.
以上显示的是最相近的搜索结果。 查看全部搜索结果