Amphetamine-induced increases in extracellular dopamine, drug wanting, and novelty seeking: a PET/[11C] raclopride study in healthy men
M Leyton, I Boileau, C Benkelfat, M Diksic… - …, 2002 - Elsevier
Eight healthy men underwent two positron emission tomography (PET)[11C] raclopride
scans, one following placebo, the second following d-amphetamine (0.30 mg/kg, po). PET
data were analyzed using:(1) brain parametric maps to statistically generate regions of
significant change; and (2) a priori identified regions of interest (ROI) manually drawn on
each individual's co-registered magnetic resonance (MR) images. Compared with placebo,
d-amphetamine decreased [11C] raclopride binding potential (BP) with significant effects in …
scans, one following placebo, the second following d-amphetamine (0.30 mg/kg, po). PET
data were analyzed using:(1) brain parametric maps to statistically generate regions of
significant change; and (2) a priori identified regions of interest (ROI) manually drawn on
each individual's co-registered magnetic resonance (MR) images. Compared with placebo,
d-amphetamine decreased [11C] raclopride binding potential (BP) with significant effects in …
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