Amyloid Beta‐Peptide Increases BACE1 Translation through the Phosphorylation of the Eukaryotic Initiation Factor‐2α
P Picón-Pagès, DA Gutiérrez… - Oxidative Medicine …, 2020 - Wiley Online Library
Alzheimer's disease (AD) is tightly linked to oxidative stress since amyloid beta‐peptide (Aβ)
aggregates generate free radicals. Moreover, the aggregation of Aβ is increased by
oxidative stress, and the neurotoxicity induced by the oligomers and fibrils is in part
mediated by free radicals. Interestingly, it has been reported that oxidative stress can also
induce BACE1 transcription and expression. BACE1 is the key enzyme in the cleavage of
the amyloid precursor protein to produce Aβ, and the expression of this enzyme has been …
aggregates generate free radicals. Moreover, the aggregation of Aβ is increased by
oxidative stress, and the neurotoxicity induced by the oligomers and fibrils is in part
mediated by free radicals. Interestingly, it has been reported that oxidative stress can also
induce BACE1 transcription and expression. BACE1 is the key enzyme in the cleavage of
the amyloid precursor protein to produce Aβ, and the expression of this enzyme has been …
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