Amyloid precursor protein (APP) is a membrane protein expressed in several tissues. The
occurrence of APP is predominant in synapses of nerve cells. It acts as a cell surface
receptor and plays a vital role as a regulator of synapse formation, iron export and neural
plasticity. It is encoded by the APP gene that is regulated by substrate presentation. APP is a
precursor protein activated by proteolytic cleavage and thereby generating amyloid beta
(Aβ) peptides which eventually form amyloid plaques that accumulate in Alzheimer's …

Alzheimer's disease (AD) is one of the most common neurodegenerative disorders
associated with age or inherited mutations. It is characterized by severe dementia in the late
stages that affect memory, cognitive functions, and daily life overall. AD progression is linked
to the accumulation of cytotoxic amyloid beta (Aβ) and hyperphosphorylated tau protein
combined with other pathological features such as synaptic loss, defective energy
metabolism, imbalances in protein, and metal homeostasis. Several treatment options for AD …