An efficient method for the preparation of 1-hydroxy-5, 8-dimethoxy-2-naphthaldehyde (1)
was developed with a high overall yield (73.8%). Compared with the previously reported
method, the reaction conditions are milder and the work-up of each step is much simpler.
Moreover, the starting material considerably reduces the cost and is suitable for large-scale
preparations. Naphthoquinone derivatives have attracted considerable interests by
scientists due to its beneficial biological activities, such as antitumor, 1, 2 antiviral, 3 …