[PDF][PDF] An aptamer targeting the apical-loop domain modulates pri-miRNA processing
CE Lunse, G Michlewski, CS Hopp… - Angew Chem Int …, 2010 - limes-institut-bonn.de
Angew Chem Int Ed Engl, 2010•limes-institut-bonn.de
MicroRNAs (miRNAs) are short noncoding RNAs that recognize complementary bases on
target mRNAs, thereby triggering either inhibition of translation initiation or mRNA
degradation.[1, 2] They have unique expression patterns and are involved in almost every
important biological process, including cell proliferation, differentiation, and apoptosis.[3] In
turn, deregulation of miRNA expression patterns is a key condition in the onset and
progression of tumor development.[4, 5] Following the synthesis of the primary transcript …
target mRNAs, thereby triggering either inhibition of translation initiation or mRNA
degradation.[1, 2] They have unique expression patterns and are involved in almost every
important biological process, including cell proliferation, differentiation, and apoptosis.[3] In
turn, deregulation of miRNA expression patterns is a key condition in the onset and
progression of tumor development.[4, 5] Following the synthesis of the primary transcript …
MicroRNAs (miRNAs) are short noncoding RNAs that recognize complementary bases on target mRNAs, thereby triggering either inhibition of translation initiation or mRNA degradation.[1, 2] They have unique expression patterns and are involved in almost every important biological process, including cell proliferation, differentiation, and apoptosis.[3] In turn, deregulation of miRNA expression patterns is a key condition in the onset and progression of tumor development.[4, 5]
Following the synthesis of the primary transcript (primiRNA), the maturation process of miRNAs comprises several steps.[6] First, the pri-miRNA is hydrolyzed by the microprocessor complex, consisting of Drosha/DGCR8, to release hairpin-shaped precursor RNAs (pre-miRNAs). Subsequently, the pre-miRNA is exported into the cytoplasm and further processed by the typeIII ribonuclease Dicer to produce mature miRNAs.
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