An ensemble method for identifying regulatory circuits with special reference to the qa gene cluster of Neurospora crassa
D Battogtokh, DK Asch, ME Case… - Proceedings of the …, 2002 - National Acad Sciences
D Battogtokh, DK Asch, ME Case, J Arnold, HB Schüttler
Proceedings of the National Academy of Sciences, 2002•National Acad SciencesA chemical reaction network for the regulation of the quinic acid (qa) gene cluster of
Neurospora crassa is proposed. An efficient Monte Carlo method for walking through the
parameter space of possible chemical reaction networks is developed to identify an
ensemble of deterministic kinetics models with rate constants consistent with RNA and
protein profiling data. This method was successful in identifying a model ensemble fitting
available RNA profiling data on the qa gene cluster.
Neurospora crassa is proposed. An efficient Monte Carlo method for walking through the
parameter space of possible chemical reaction networks is developed to identify an
ensemble of deterministic kinetics models with rate constants consistent with RNA and
protein profiling data. This method was successful in identifying a model ensemble fitting
available RNA profiling data on the qa gene cluster.
A chemical reaction network for the regulation of the quinic acid (qa) gene cluster of Neurospora crassa is proposed. An efficient Monte Carlo method for walking through the parameter space of possible chemical reaction networks is developed to identify an ensemble of deterministic kinetics models with rate constants consistent with RNA and protein profiling data. This method was successful in identifying a model ensemble fitting available RNA profiling data on the qa gene cluster.
National Acad Sciences
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