The purpose of this study was to explore the factors that influence entrepreneurial intentions among students in Ghana. The research was carried out by a survey method. Questionnaires were used to collect data from 731 undergraduate students pursuing regular and part-time programmes in a Ghanaian public university. Data were analysed using correlation and multiple regression analysis through the SPSS. Results of standard multiple regression showed that six out of the 23 factors explored in the study significantly influenced student entrepreneurial intention. A follow-up forward regression analysis showed that exposure to other entrepreneurs and experienced network is the most significant predictor of student entrepreneurial intentions. This was followed by dissatisfaction with previous job. The findings further showed that utilization of better opportunity in the market least predicted student entrepreneurial intention. This study contributes to the pool of knowledge by revealing the factors that influence the entrepreneurial intention of Ghanaian tertiary students. This is very significant to the development of entrepreneurial activities in Ghana especially in developing curriculum for entrepreneurial education and governmental policies to boost entrepreneurship in the nation.