In this paper, the effect of feed rate, voltage, and flow rate of electrolyte on some performance parameters such as surface roughness, material removal rate, and over-cut of SAE-XEV-F valve-steel during electrochemical drilling in NaCl and NaNo₃ electrolytic solutions have been studied using the main effect plot, the interaction plot and the ANOVA analysis. In continuation, in this case which the training dataset was small, an investigation has been done on the capability of the optimum presented regression analysis (RA), artificial neural network (ANN), and co-active neuro-fuzzy inference system (CANFIS) to predict the surface roughness, material removal rate and over-cut. The predicted parameters by the employed models have been compared with the experimental data. The comparison of results indicated that in electrochemical drilling using different electrolytic solutions, CANFIS gives the best results to predict the surface roughness and over-cut as well, while ANN is the best for predicting the material removal rate.