[HTML][HTML] Analysis of quinolone resistance due to mutational changes in escherichia coli associated with urinary tract infections: A study from North East India
N Dasgupta, D Paul, D Dhar, A Chakravarty… - International Journal of …, 2016 - ijidonline.com
Background: Background: Quinolone group of antibiotics are predominantly used drugs for
treatment of urinary tract infections. However, in recent decade's treatment failure to this drug
is due to bacterial adaptation by acquisition of plasmid mediated quinolone resistance
determinants. There also exists an intrinsic resistance mechanism by mutational changes in
bacteria in type II and type IV bacterial topoisomerase. The study was designed to analysis
point mutation in the gyrA and parC gene leading quinolone resistance in uropathogenic …
treatment of urinary tract infections. However, in recent decade's treatment failure to this drug
is due to bacterial adaptation by acquisition of plasmid mediated quinolone resistance
determinants. There also exists an intrinsic resistance mechanism by mutational changes in
bacteria in type II and type IV bacterial topoisomerase. The study was designed to analysis
point mutation in the gyrA and parC gene leading quinolone resistance in uropathogenic …
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