SIR–Alterations in the serotonergic system have been related to the origin of depression.
The serotonin 1A receptor gene is a strong candidate for major depression because of
involvement in antidepressant response and control of intersynaptic serotonin release.
Genetic alterations in the 5-HT1A gene may be related to the receptor involvement in
depression. A sample of 249 patients with major depression and 170 controls were
analysed for four different polymorphisms of the 5-HT1A receptor gene. No differences in …

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