Analysis of telomere length and function in radiosensitive mouse and human cells in response to DNA-PKcs inhibition
H Yasaei, Y Gozaly-Chianea, P Slijepcevic - Genome integrity, 2013 - Springer
Background Telomeres, the physical ends of chromosomes, play an important role in
preserving genomic integrity. This protection is supported by telomere binding proteins
collectively known as the shelterin complex. The shelterin complex protects chromosome
ends by suppressing DNA damage response and acting as a regulator of telomere length
maintenance by telomerase, an enzyme that elongates telomeres. Telomere dysfunction
manifests in different forms including chromosomal end-to-end fusion, telomere shortening …
preserving genomic integrity. This protection is supported by telomere binding proteins
collectively known as the shelterin complex. The shelterin complex protects chromosome
ends by suppressing DNA damage response and acting as a regulator of telomere length
maintenance by telomerase, an enzyme that elongates telomeres. Telomere dysfunction
manifests in different forms including chromosomal end-to-end fusion, telomere shortening …
[HTML][HTML] Analysis of telomere length and function in radiosensitive mouse and human cells in response to DNA-PKcs inhibition
P Slijepcevic, Y Gozaly-Chianea, H Yasaei - 2013 - oa.las.ac.cn
Background Telomeres, the physical ends of chromosomes, play an important role in
preserving genomic integrity. This protection is supported by telomere binding proteins
collectively known as the shelterin complex. The shelterin complex protects chromosome
ends by suppressing DNA damage response and acting as a regulator of telomere length
maintenance by telomerase, an enzyme that elongates telomeres. Telomere dysfunction
manifests in different forms including chromosomal end-to-end fusion, telomere shortening …
preserving genomic integrity. This protection is supported by telomere binding proteins
collectively known as the shelterin complex. The shelterin complex protects chromosome
ends by suppressing DNA damage response and acting as a regulator of telomere length
maintenance by telomerase, an enzyme that elongates telomeres. Telomere dysfunction
manifests in different forms including chromosomal end-to-end fusion, telomere shortening …
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