This review mainly elaborates on the animal models available for understanding the
pathogenesis of the second hit of non-alcoholic fatty liver disease (NAFLD) involving
immune system. This is known to be a step forward from simple steatosis caused during the
first hit, which leads to the stage of inflammation followed by more serious liver conditions
like non-alcoholic steatohepatitis (NASH) and cirrhosis. Immune-deficient animal models
serve as an important tool for understanding the role of a specific cell type or a cytokine in …

This review mainly elaborates on the animal models available for understanding the
pathogenesis of the second hit of non-alcoholic fatty liver disease (NAFLD) involving
immune system. This is known to be a step forward from simple steatosis caused during the
first hit, which leads to the stage of inflammation followed by more serious liver conditions
like non-alcoholic steatohepatitis (NASH) and cirrhosis. Immune-deficient animal models
serve as an important tool for understanding the role of a specific cell type or a cytokine in …