Anionic porphyrin-grafted porous silicon nanoparticles for photodynamic therapy

E Secret, M Maynadier, A Gallud… - Chemical …, 2013 - pubs.rsc.org
E Secret, M Maynadier, A Gallud, M Gary-Bobo, A Chaix, E Belamie, P Maillard, MJ Sailor
Chemical Communications, 2013pubs.rsc.org
… Some forms of photochemically active porous Si have been shown to photosensitize singlet
oxygen, 14 although the quantum yield for singlet oxygen production from porous Si is generally
low, especially in serum. To date only one study has been reported on the immobilization of
porphyrin photosensitizers in … In this case, however, the porphyrins were physisorbed in a
photochemically inactive oxidized porous Si matrix. Here we present the chemical
functionalization of pSiNP with a photosensitizer, by the covalent anchoring of a porphyrin into the …
Non-toxic porous silicon nanoparticles carry porphyrin covalently attached to their surface inside breast cancer cells for a more efficient photodynamic effect.
The Royal Society of Chemistry
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