Anti-AIDS agents. 48. Anti-HIV activity of moronic acid derivatives and the new melliferone-related triterpenoid isolated from Brazilian propolis
J Ito, FR Chang, HK Wang, YK Park… - Journal of natural …, 2001 - ACS Publications
Journal of natural Products, 2001•ACS Publications
A new triterpenoid named melliferone (1), three known triterpenoids, moronic acid (2),
anwuweizonic acid (3), and betulonic acid (4), and four known aromatic compounds (5− 8)
were isolated from Brazilian propolis and tested for anti-HIV activity in H9 lymphocytes.
Moronic acid (2) showed significant anti-HIV activity (EC50< 0.1 μg/mL, TI> 186) and was
modified to develop more potent anti-AIDS agents.
anwuweizonic acid (3), and betulonic acid (4), and four known aromatic compounds (5− 8)
were isolated from Brazilian propolis and tested for anti-HIV activity in H9 lymphocytes.
Moronic acid (2) showed significant anti-HIV activity (EC50< 0.1 μg/mL, TI> 186) and was
modified to develop more potent anti-AIDS agents.
A new triterpenoid named melliferone (1), three known triterpenoids, moronic acid (2), anwuweizonic acid (3), and betulonic acid (4), and four known aromatic compounds (5−8) were isolated from Brazilian propolis and tested for anti-HIV activity in H9 lymphocytes. Moronic acid (2) showed significant anti-HIV activity (EC50 <0.1 μg/mL, TI >186) and was modified to develop more potent anti-AIDS agents.
ACS Publications