The process involving new blood vessel sprouting from already existing ones is regulated by
a physiological complex mechanism, known as angiogenesis. It plays a key role in wound
healing but is also present in pathophysiological conditions such as cancer and
cardiovascular disease, which have the highest rates of morbidity and mortality worldwide. It
is stimulated mechanically or chemically, with the latter involving several signaling pathways
and proteins widely known as growth factors. Anti-angiogenesis has always been an …