Anti-inflammatory and analgesic properties of water–ethanolic extract from Pothomorphe umbellata (Piperaceae) aerial parts

FF Perazzo, GHB Souza, W Lopes… - Journal of …, 2005 - Elsevier
FF Perazzo, GHB Souza, W Lopes, LGV Cardoso, JCT Carvalho, NPD Nanayakkara
Journal of Ethnopharmacology, 2005Elsevier
Anti-inflammatory and analgesic activities as well as the median lethal dose (LD50) of water–
ethanolic extract (PHE) of the aerial parts of Pothomorphe umbellata were evaluated in
animal models. The ED50 (oral) for the inhibition of carrageenan-induced rat paw edema
assay was determined to be 550mg/kg, while the LD50 was higher than 2.0 g/kg. At a dose
of 550mg/kg, PHE inhibited the inflammatory process by 48.7%(P< 0.05) on the third hour of
the assay (edema peak) when compared to the untreated control. Indomethacin, the positive …
Anti-inflammatory and analgesic activities as well as the median lethal dose (LD50) of water–ethanolic extract (PHE) of the aerial parts of Pothomorphe umbellata were evaluated in animal models. The ED50 (oral) for the inhibition of carrageenan-induced rat paw edema assay was determined to be 550mg/kg, while the LD50 was higher than 2.0g/kg. At a dose of 550mg/kg, PHE inhibited the inflammatory process by 48.7% (P<0.05) on the third hour of the assay (edema peak) when compared to the untreated control. Indomethacin, the positive control used in this test, inhibited the edema by 58.6% at a dose of 10mg/kg, when compared to the untreated control (P<0.05). All three fractions – hexane, methylene chloride and ethyl acetate – obtained by partition of PHE with respective solvents also showed inhibition of the edema induced by carrageenan over a period of 4h but the methylene chloride fraction showed the best activity. The activity shown by the methylene chloride fraction at 200mg/kg was comparable to that exhibited by indomethacin at a dose of 10mg/kg. The number of writhings induced by a 0.6% acetic acid solution intraperitoneal injection was decreased by 22% (P<0.05) in the group treated orally with Pothomorphe umbellata crude extract. PHE also inhibited the granulomatous tissue formation in rats by 6.2% (P<0.05). In the same assay, topically applied dexamethasone decreased the granuloma formation by 14.2%. The above results suggest that Pothomorphe umbellata crude extract has analgesic and anti-inflammatory properties supporting its folkloric use for the treatment of these conditions.
Elsevier
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