Antibodies Against Glycolipids Enhance Antifungal Activity of Macrophages and Reduce Fungal Burden After Infection with Paracoccidioides brasiliensis
RA Bueno, L Thomaz, JE Muñoz, CJ Da Silva… - Frontiers in …, 2016 - frontiersin.org
Paracoccidioidomycosis is a fungal disease endemic in Latin America. Polyclonal
antibodies to acidic glycosphingolipids (GSLs) from Paracoccidioides brasiliensis opsonized
yeast forms in vitro increasing phagocytosis and reduced the fungal burden of infected
animals. Antibodies to GSL were active in both prophylactic and therapeutic protocols using
a murine intratracheal infection model. Pathological examination of the lungs of animals
treated with antibodies to GSL showed well-organized granulomas and minimally damaged …
antibodies to acidic glycosphingolipids (GSLs) from Paracoccidioides brasiliensis opsonized
yeast forms in vitro increasing phagocytosis and reduced the fungal burden of infected
animals. Antibodies to GSL were active in both prophylactic and therapeutic protocols using
a murine intratracheal infection model. Pathological examination of the lungs of animals
treated with antibodies to GSL showed well-organized granulomas and minimally damaged …
[引用][C] Antibodies against glycolipids enhance antifungal activity of macrophages and reduce fungal burden after infection with Paracoccidioides brasiliensis
R Amelia eBueno, J Esteban eMuñoz, JD Nosanchuk… - 2016
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