Antioxidant activities and cytotoxicity of selected coumarin derivatives: preliminary results of a structure–activity relationship study using computational tools
RN Gacche, SG Jadhav - Journal of Experimental & Clinical Medicine, 2012 - Elsevier
PURPOSE: In the present investigation a series of coumarin derivatives (CDs) were
evaluated for their in vitro antioxidant and anticancer activities. This study was to assess the
suitability of a series of structurally different CDs as possible antioxidant and anticancer
agents. METHODS: The antioxidant studies were carried out using a 2, 2,-diphenyl-1-
picrylhydrazine (DPPH) radical scavenging assay, while the anticancer activity was
assessed by performing the (4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazoliuum bromide …
evaluated for their in vitro antioxidant and anticancer activities. This study was to assess the
suitability of a series of structurally different CDs as possible antioxidant and anticancer
agents. METHODS: The antioxidant studies were carried out using a 2, 2,-diphenyl-1-
picrylhydrazine (DPPH) radical scavenging assay, while the anticancer activity was
assessed by performing the (4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazoliuum bromide …
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