Antiphosphatidylserine/prothrombin antibodies (aPS/PT) as potential markers of antiphospholipid syndrome
A Vlagea, A Gil, MV Cuesta, F Arribas… - Clinical and Applied …, 2013 - journals.sagepub.com
A Vlagea, A Gil, MV Cuesta, F Arribas, J Diez, P Lavilla, D Pascual-Salcedo
Clinical and Applied Thrombosis/Hemostasis, 2013•journals.sagepub.comThe antiphospholipid antibodies present in antiphospholipid syndrome (APS) are directed at
a number of phospholipid-binding proteins: β2 glycoprotein I (β2GPI), prothrombin, and so
on. Antibodies directed at β2GPI are accepted as a classification criterion for APS, while the
presence of antiprothrombin antibodies is not. In the present article, we investigated the
possible role of antiphosphatidylserine/prothrombin antibodies (aPS/PT) as marker of APS
on a cohort of 295 individuals with APS (95 primary APS and 45 secondary APS) and APS …
a number of phospholipid-binding proteins: β2 glycoprotein I (β2GPI), prothrombin, and so
on. Antibodies directed at β2GPI are accepted as a classification criterion for APS, while the
presence of antiprothrombin antibodies is not. In the present article, we investigated the
possible role of antiphosphatidylserine/prothrombin antibodies (aPS/PT) as marker of APS
on a cohort of 295 individuals with APS (95 primary APS and 45 secondary APS) and APS …
The antiphospholipid antibodies present in antiphospholipid syndrome (APS) are directed at a number of phospholipid-binding proteins: β2 glycoprotein I (β2GPI), prothrombin, and so on. Antibodies directed at β2GPI are accepted as a classification criterion for APS, while the presence of antiprothrombin antibodies is not. In the present article, we investigated the possible role of antiphosphatidylserine/prothrombin antibodies (aPS/PT) as marker of APS on a cohort of 295 individuals with APS (95 primary APS and 45 secondary APS) and APS-related diseases. We found aPS/PT to be highly associated with venous thrombosis (immunoglobulin G [IgG] aPS/PT odds ratio [OR], 7.44; 95% confidence interval [CI], 3.97-13.92 and IgM aPS/PT OR, 2.54; 95% CI, 1.35-4.77) and obstetric abnormalities (IgG aPS/PT OR, 2.37; 95% CI, 1.04-5.43), but not with arterial thrombosis. A very high degree of concordance between the concentration of aPS/PT and lupus anticoagulant activity was demonstrated. Therefore, we support the inclusion of aPS/PT determination as second-level assay to confirm APS classification.
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