Identification of cellular surface markers that distinguish tumorous from normal vasculature is
important for the development of tumor vessel-targeted therapy. Here, we show that Apj, a G
protein-coupled receptor, is highly enriched in tumor endothelial cells but absent from most
endothelial cells of adult tissues in homeostasis. By genetic targeting using Apj-CreER and
Apj-DTRGFP-Luciferase, we demonstrated that hypoxia-VEGF signaling drives expansion of
Apj+ tumor vessels and that targeting of these vessels, genetically and pharmacologically …

(Cell Reports 25, 1241–1254. e1–e5; October 30, 2018) In the original version of the paper
published with the October 30, 2018 issue, incorrect H&E images were inadvertently
inserted into Figure S4B (muscle) and Figure S6B (brain) due to a mistake during figure
assembly. The corrected versions of the figures can be seen below alongside the original
versions of the figures. The corrections do not affect the conclusion of this paper. The
authors sincerely apologize for any confusion that the error may have caused.